The problem with this design is you're entirely reliant on the bike's tire pressure to hold your bike securely. In the case of a road trip where you're changing elevation and temperature, if your bike tires lose any air, your bike is no longer safe.
The issue here is fork rub. The oscillation of the bike both on and off-road over time will rub and scuff the fork lowers. In addition, the asymmetrical trays create a potential bite point for tacoing a wheel in a hard deceleration.
The issue clamping the frame is it puts your frame at risk of being damaged whether from rubbing and scuffing over time or the risk of an impact to frame in the event of a sudden jolt caused by an abrupt deceleration (having to slam on the brakes) or harsh compression while driving on or off-road.
Load your bike into the deep symmetrical wheel tray, then lock the arm in the vertical position. Even with a completely flat tire, your bike can’t bounce out of the rack. VertLock™ technology also avoids any potential fork or frame damage. Learn more about the RambleRack® here.